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Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors.


ABSTRACT: OBJECTIVES:The aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared. METHODS:Demographics, risk factors, disease duration, management and outcomes of 224 children and 1063 adults were compared using appropriate statistical tests for categorical and continuous variables. RESULTS:Alcohol was a risk in 53% of adults and 1% of children (P?

SUBMITTER: Schwarzenberg SJ 

PROVIDER: S-EPMC6492264 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors.

Schwarzenberg Sarah J SJ   Uc Aliye A   Zimmerman Bridget B   Wilschanski Michael M   Wilcox C Mel CM   Whitcomb David C DC   Werlin Steven L SL   Troendle David D   Tang Gong G   Slivka Adam A   Singh Vikesh K VK   Sherman Stuart S   Shah Uzma U   Sandhu Bimaljit S BS   Romagnuolo Joseph J   Rhee Sue S   Pohl John F JF   Perito Emily R ER   Ooi Chee Y CY   Nathan Jaimie D JD   Muniraj Thiruvengadam T   Morinville Veronique D VD   McFerron Brian B   Mascarenhas Maria M   Maqbool Asim A   Liu Quin Q   Lin Tom K TK   Lewis Michele M   Husain Sohail Z SZ   Himes Ryan R   Heyman Melvin B MB   Guda Nalini N   Gonska Tanja T   Giefer Matthew J MJ   Gelrud Andres A   Gariepy Cheryl E CE   Gardner Timothy B TB   Freedman Steven D SD   Forsmark Christopher E CE   Fishman Douglas S DS   Cote Gregory A GA   Conwell Darwin D   Brand Randall E RE   Bellin Melena M   Barth Bradley B   Banks Peter A PA   Anderson Michelle A MA   Amann Stephen T ST   Alkaade Samer S   Abu-El-Haija Maisam M   Abberbock Judah N JN   Lowe Mark E ME   Yadav Dhiraj D  

Journal of pediatric gastroenterology and nutrition 20190401 4


<h4>Objectives</h4>The aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared.<h4>Methods</h4>Demographics, risk factors, disease duration, management and outcomes of 224 children and 1063 adults were compared using appropriate statistical tests for categorical and continuous var  ...[more]

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