Resting-state connectivity and modulated somatomotor and default-mode networks in Huntington disease.

ABSTRACT:

Aims

To analyze brain functional connectivity in the somatomotor and default-mode networks (DMNs) of patients with Huntington disease (HD), its relationship with gray matter (GM) volume loss, and functional changes after pridopidine treatment.

Methods

Ten patients and ten untreated controls underwent T1-weighted imaging and resting-state functional magnetic resonance imaging (fMRI); four patients were also assessed after 3 months of pridopidine treatment (90 mg/d). The seed-based functional connectivity patterns from the posterior cingulate cortex and the supplementary motor area (SMA), considered cortical hubs of the DMN and somatomotor networks, respectively, were computed. FMRIB Software Library voxel-based morphometry measured GM volume.

Results

Patients had GM vo

SUBMITTER: Sanchez-Castaneda C 

PROVIDER: S-EPMC6492661 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature