Dataset Information

Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma.

ABSTRACT:

Aims

To explore the prognostic and clinicopathological features of glioma with Paxillin (PXN) expression based on a large number of samples.

Methods

RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate the survival distributions. Moreover, the functional annotation of PXN was also analyzed.

Results

In the discovery set, PXN overexpression was significantly associated with high-grade glioma as well as the higher mortality in survival analysis (log-rank test, P < 0.01). The results of the other validation datasets showed similar findings. PXN also served as an independent prognostic biomarker in glioblastoma patients. Functional assays showed that PXN contributed to glioma cell proliferation and invasion.

Conclusion

PXN plays as an oncogene in glioma progression and suggests a new potential biotarget for therapy.

SUBMITTER: Sun LH

PROVIDER: S-EPMC6492676 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Publications

Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma.

Sun Li-Hua LH Yang Fu-Qiang FQ Zhang Chuan-Bao CB Wu Yi-Ping YP Liang Jing-Shan JS Jin Shuai S Wang Zheng Z Wang Hong-Jun HJ Bao Zhao-Shi ZS Yang Zheng-Xiang ZX Jiang Tao T

CNS neuroscience & therapeutics 20160917 1

<h4>Aims</h4>To explore the prognostic and clinicopathological features of glioma with Paxillin (PXN) expression based on a large number of samples.<h4>Methods</h4>RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) database were obtained as discovery set. Three additional datasets were further obtained as validation sets. The protein expression pattern of PXN in glioma was measured by IHC. Kaplan-Meier survival and multivariate Cox analysis were used to estimate th ...[more]

PMID: 27637748

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Dataset Information

Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma.

Aims

Methods

Results

Conclusion

Publications

Overexpression of Paxillin Correlates with Tumor Progression and Predicts Poor Survival in Glioblastoma.

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