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Enlarged perivascular spaces are associated with health-related quality of life in patients with acute ischemic stroke.


ABSTRACT:

Aims

This study explored the association between enlarged perivascular spaces (EPVS) and the health-related quality of life (HRQoL) in patients with acute ischemic stroke.

Methods

This was an observational study of consecutively screened patients with acute ischemic stroke from March 2010 to March 2015. EPVS were rated in the basal ganglia and the centrum semiovale with a validated scale. The HRQoL was assessed 3 months after the stroke onset using the Stroke-Specific Quality of Life (SSQoL). Linear regression models were used to study the association between EPVS and HRQoL.

Results

The study included 648 patients (mean age 65.8 years; 40.0% women) with mild to moderately severe stroke (median NIHSS score 2), of whom 640 (98.8%) exhibited signs of small vessel disease. The median EPVS scores in the basal ganglia and the centrum semiovale were 1 each. In linear regression analysis, EPVS in the basal ganglia were associated with a lower total SSQoL score (P = 0.02) and lower mobility (P = 0.01), mood (P = 0.03), and self-care (P < 0.01). EPVS in the centrum semiovale were associated only with a lower SSQoL work/productivity subscore (P = 0.002).

Conclusions

EPVS are associated with lower HRQoL in patients with mild to moderate acute ischemic stroke. Early identification and intervention of EPVS may improve HRQoL in stroke survivors.

SUBMITTER: Liang Y 

PROVIDER: S-EPMC6492717 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Publications

Enlarged perivascular spaces are associated with health-related quality of life in patients with acute ischemic stroke.

Liang Yan Y   Deng Min M   Chen Yang-Kun YK   Mok Vincent V   Wang De-Feng DF   Ungvari Gabor S GS   Chu Chiu-Wing Winnie CW   Berge Eivind E   Tang Wai-Kwong WK  

CNS neuroscience & therapeutics 20171020 12


<h4>Aims</h4>This study explored the association between enlarged perivascular spaces (EPVS) and the health-related quality of life (HRQoL) in patients with acute ischemic stroke.<h4>Methods</h4>This was an observational study of consecutively screened patients with acute ischemic stroke from March 2010 to March 2015. EPVS were rated in the basal ganglia and the centrum semiovale with a validated scale. The HRQoL was assessed 3 months after the stroke onset using the Stroke-Specific Quality of L  ...[more]

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