α-Mangostin decreases β-amyloid peptides production via modulation of amyloidogenic pathway.

ABSTRACT:

Aims

β-amyloid (Aβ) aggregation and deposition play a central role in the pathogenic process of Alzheimer's disease (AD). α-Mangostin (α-M), a polyphenolic xanthone, have been shown to dissociate Aβ oligomers. In this study, we further investigated the effect of α-M on Aβ production and its molecular mechanism.

Methods

The Aβ and soluble amyloid precursor protein α (sAPPα) in culture medium of cortical neurons were measured by ELISA. The activities of α-, β-, and γ-secretases were assayed, and the interaction between α-M and β- or γ-secretases was simulated by molecular docking.

Results

α-M significantly decreased Aβ₄₀ and Aβ₄₂ production. α-M did not affect the expression of enzymes involved in nonamyloidogenic and amyloidogenic pathways, but si

SUBMITTER: Zhao LX 

PROVIDER: S-EPMC6492755 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature