Ontology highlight
ABSTRACT:
SUBMITTER: Mallio CA
PROVIDER: S-EPMC6493130 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Mallio Carlo Augusto CA Schmidt Ruben R de Reus Marcel A MA Vernieri Fabrizio F Quintiliani Livia L Curcio Giuseppe G Beomonte Zobel Bruno B Quattrocchi Carlo Cosimo CC van den Heuvel Martijn P MP
CNS neuroscience & therapeutics 20150421 10
<h4>Aims</h4>Neurodegenerative changes observed in Alzheimer's disease (AD) have been suggested to begin at the entorhinal cortex and hippocampus and then to propagate in a stereotypical fashion. Using diffusion-weighted imaging, we test whether disruption of structural connectivity in AD is centered on these "epicenters of disease".<h4>Methods</h4>Fifteen healthy controls, 14 amnestic mild cognitive impairment (aMCI), 13 mild, and 15 moderate patients with AD were enrolled. The percentages of a ...[more]