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Test-retest reliability of graph metrics in high-resolution functional connectomics: a resting-state functional MRI study.


ABSTRACT:

Background

The combination of resting-state functional MRI (R-fMRI) technique and graph theoretical approaches has emerged as a promising tool for characterizing the topological organization of brain networks, that is, functional connectomics. In particular, the construction and analysis of high-resolution brain connectomics at a voxel scale are important because they do not require prior regional parcellations and provide finer spatial information about brain connectivity. However, the test-retest reliability of voxel-based functional connectomics remains largely unclear.

Aims

This study tended to investigate both short-term (?20 min apart) and long-term (6 weeks apart) test-retest (TRT) reliability of graph metrics of voxel-based brain networks.

Methods

Based on graph theoretical approaches, we analyzed R-fMRI data from 53 young healthy adults who completed two scanning sessions (session 1 included two scans 20 min apart; session 2 included one scan that was performed after an interval of ?6 weeks).

Results

The high-resolution networks exhibited prominent small-world and modular properties and included functional hubs mainly located at the default-mode, salience, and executive control systems. Further analysis revealed that test-retest reliabilities of network metrics were sensitive to the scanning orders and intervals, with fair to excellent long-term reliability between Scan 1 and Scan 3 and lower reliability involving Scan 2. In the long-term case (Scan 1 and Scan 3), most network metrics were generally test-retest reliable, with the highest reliability in global metrics in the clustering coefficient and in the nodal metrics in nodal degree and efficiency.

Conclusion

We showed high test-retest reliability for graph properties in the high-resolution functional connectomics, which provides important guidance for choosing reliable network metrics and analysis strategies in future studies.

SUBMITTER: Du HX 

PROVIDER: S-EPMC6493187 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Test-retest reliability of graph metrics in high-resolution functional connectomics: a resting-state functional MRI study.

Du Hai-Xiao HX   Liao Xu-Hong XH   Lin Qi-Xiang QX   Li Gu-Shu GS   Chi Yu-Ze YZ   Liu Xiang X   Yang Hua-Zhong HZ   Wang Yu Y   Xia Ming-Rui MR  

CNS neuroscience & therapeutics 20150727 10


<h4>Background</h4>The combination of resting-state functional MRI (R-fMRI) technique and graph theoretical approaches has emerged as a promising tool for characterizing the topological organization of brain networks, that is, functional connectomics. In particular, the construction and analysis of high-resolution brain connectomics at a voxel scale are important because they do not require prior regional parcellations and provide finer spatial information about brain connectivity. However, the  ...[more]

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