Ontology highlight
ABSTRACT:
SUBMITTER: Cunin P
PROVIDER: S-EPMC6494422 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Cunin Pierre P Bouslama Rim R Machlus Kellie R KR Martínez-Bonet Marta M Lee Pui Y PY Wactor Alexandra A Nelson-Maney Nathan N Morris Allyn A Guo Li L Weyrich Andrew A Sola-Visner Martha M Boilard Eric E Italiano Joseph E JE Nigrovic Peter A PA
eLife 20190501
Bone marrow megakaryocytes engulf neutrophils in a phenomenon termed emperipolesis. We show here that emperipolesis is a dynamic process mediated actively by both lineages, in part through the β2-integrin/ICAM-1/ezrin pathway. Tethered neutrophils enter in membrane-bound vesicles before penetrating into the megakaryocyte cytoplasm. Intracytoplasmic neutrophils develop membrane contiguity with the demarcation membrane system, thereby transferring membrane to the megakaryocyte and to daughter plat ...[more]