Ontology highlight
ABSTRACT:
SUBMITTER: Yousafzai NA
PROVIDER: S-EPMC6494911 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Yousafzai Neelum Aziz NA Zhou Qiyin Q Xu Wenxia W Shi Qiqi Q Xu Jinye J Feng Lifeng L Chen Hui H Shin Vivian Yvonne VY Jin Hongchuan H Wang Xian X
Cell death & disease 20190501 5
Chemoresistance is one of the most important challenges in the clinical management of lung cancer. SIRT1 is a NAD dependent protein deacetylase and implicated in diverse cellular processes such as DNA damage repair, and cancer progression. SIRT1 is upregulated in chemoresistant lung cancer cells, genetic knockdown or chemical inhibition of SIRT1 reversed chemoresistance by enhancing DNA damage and apoptosis activation, accompanied with XRCC1 degradation. E3 ligase β-TrCP catalyzed the poly-ubiqu ...[more]