Pregnancy loss and risk of later dementia: A nationwide cohort study, Denmark, 1977-2017.

ABSTRACT:

Introduction

Pregnancy losses may be associated with increased risks of dementia.

Methods

We conducted a register-based cohort study in 1,243,957 women with ≥1 pregnancy in Denmark in the period 1977-2015. Using Cox regression, we estimated hazard ratios (HRs) comparing risks of dementia in women with and without pregnancy losses.

Results

During 21,672,433 person-years of follow-up, 261,279 women experienced a pregnancy loss, and 2188 women were diagnosed with dementia. Stillbirth was associated with an 86% increased risk of dementia overall (HR 1.86, 95% confidence interval [CI] 1.28-2.71). By contrast, miscarriage was not associated with later risk of dementia overall (single miscarriage, HR 0.99, 95% CI 0.87-1.12; recurrent miscarriages, HR 1.06, 95% CI 0.84-1.35).

SUBMITTER: Basit S 

PROVIDER: S-EPMC6495073 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature