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ABSTRACT: Aims
The postictal suppression (PS) is a common and important period following an epileptic seizure but has not been well studied. This study was designed to determine whether interleukin-1? (IL-1?) is involved in the PS.Methods
The effects of IL-1? on the PS were tested in three independent seizure models induced by hippocampal kindling, maximal electroshock seizure (MES), and 4-aminopyridine, respectively.Results
IL-1R1 knockout or IL-1RA enhanced the seizure refractory phenomenon without influencing the baseline seizure threshold in intermittent MES model. IL-1? attenuated the seizure refractory phenomenon without affecting the severity of the preceding seizures in hippocampal kindling model, while IL-1RA enhanced it. Besides, IL-1? reduced the postictal EEG suppression period, while IL-1RA prolonged it. And IL-1? showed no further effect on the postictal EEG suppression and seizure refractory phenomenon in IL-1R1 knockout mice. In addition, 30 min after intrahippocampal injection of 4-aminopyridine, IL-1? increased the incidence of SE, while IL-1RA prolonged the intervals between recurrent seizures.Conclusions
This study provides the first direct evidence that IL-1? is key regulatory factor for the PS, and its receptor IL-1R1 may be a potential target for adjuvant treatment of postictal problems.
SUBMITTER: Tao AF
PROVIDER: S-EPMC6495150 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Tao An-Feng AF Xu Zheng-Hao ZH Chen Bin B Wang Yi Y Wu Xiao-Hua XH Zhang Jing J Tang Yang-Shun YS Xu Ceng-Lin CL Zhao Hua-Wei HW Hu Wei-Wei WW Shi Li-Yun LY Zhang Shi-Hong SH Chen Zhong Z
CNS neuroscience & therapeutics 20150620 8
<h4>Aims</h4>The postictal suppression (PS) is a common and important period following an epileptic seizure but has not been well studied. This study was designed to determine whether interleukin-1β (IL-1β) is involved in the PS.<h4>Methods</h4>The effects of IL-1β on the PS were tested in three independent seizure models induced by hippocampal kindling, maximal electroshock seizure (MES), and 4-aminopyridine, respectively.<h4>Results</h4>IL-1R1 knockout or IL-1RA enhanced the seizure refractory ...[more]