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The Pro-inflammatory Cytokine Interleukin-1? is a Key Regulatory Factor for the Postictal Suppression in Mice.


ABSTRACT:

Aims

The postictal suppression (PS) is a common and important period following an epileptic seizure but has not been well studied. This study was designed to determine whether interleukin-1? (IL-1?) is involved in the PS.

Methods

The effects of IL-1? on the PS were tested in three independent seizure models induced by hippocampal kindling, maximal electroshock seizure (MES), and 4-aminopyridine, respectively.

Results

IL-1R1 knockout or IL-1RA enhanced the seizure refractory phenomenon without influencing the baseline seizure threshold in intermittent MES model. IL-1? attenuated the seizure refractory phenomenon without affecting the severity of the preceding seizures in hippocampal kindling model, while IL-1RA enhanced it. Besides, IL-1? reduced the postictal EEG suppression period, while IL-1RA prolonged it. And IL-1? showed no further effect on the postictal EEG suppression and seizure refractory phenomenon in IL-1R1 knockout mice. In addition, 30 min after intrahippocampal injection of 4-aminopyridine, IL-1? increased the incidence of SE, while IL-1RA prolonged the intervals between recurrent seizures.

Conclusions

This study provides the first direct evidence that IL-1? is key regulatory factor for the PS, and its receptor IL-1R1 may be a potential target for adjuvant treatment of postictal problems.

SUBMITTER: Tao AF 

PROVIDER: S-EPMC6495150 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Publications

The Pro-inflammatory Cytokine Interleukin-1β is a Key Regulatory Factor for the Postictal Suppression in Mice.

Tao An-Feng AF   Xu Zheng-Hao ZH   Chen Bin B   Wang Yi Y   Wu Xiao-Hua XH   Zhang Jing J   Tang Yang-Shun YS   Xu Ceng-Lin CL   Zhao Hua-Wei HW   Hu Wei-Wei WW   Shi Li-Yun LY   Zhang Shi-Hong SH   Chen Zhong Z  

CNS neuroscience & therapeutics 20150620 8


<h4>Aims</h4>The postictal suppression (PS) is a common and important period following an epileptic seizure but has not been well studied. This study was designed to determine whether interleukin-1β (IL-1β) is involved in the PS.<h4>Methods</h4>The effects of IL-1β on the PS were tested in three independent seizure models induced by hippocampal kindling, maximal electroshock seizure (MES), and 4-aminopyridine, respectively.<h4>Results</h4>IL-1R1 knockout or IL-1RA enhanced the seizure refractory  ...[more]

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