Ontology highlight
ABSTRACT:
SUBMITTER: Shen Z
PROVIDER: S-EPMC6495224 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Shen Zhe Z Jiang Lei L Yuan Yang Y Deng Tian T Zheng Yan-Rong YR Zhao Yan-Yan YY Li Wen-Lu WL Wu Jia-Ying JY Gao Jian-Qing JQ Hu Wei-Wei WW Zhang Xiang-Nan XN Chen Zhong Z
CNS neuroscience & therapeutics 20141211 3
<h4>Aim</h4>Lactates accumulate in ischemic brains. G protein-coupled receptor 81 (GPR81) is an endogenous receptor for lactate. We aimed to explore whether lactate is involved in ischemic injury via activating GPR81.<h4>Methods</h4>N2A cells were transfected with GFP-GPR81 plasmids 24 h previously, and then treated with GPR81 antagonist 3-hydroxy-butyrate (3-OBA) alone or cotreated with agonists lactate or 3, 5-dihydroxybenzoic acid (3, 5-DHBA) during 3 h of oxygen-glucose deprivation (OGD). Ad ...[more]