Dataset Information

Major Stressful Life Events and Risk of Developing Lung Cancer: A Case-Control Study.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related mortality and is strongly linked with smoking. We sought to determine whether major stressful life events (e.g. divorce) are also a risk factor for developing lung cancers.

Methods

We performed a matched case-control study. Cases (CA) were lung cancer patients diagnosed within the previous 12 months. Controls (CO) were patients without a prior history of malignancy. Data on major stressful life events were collected using the modified Holmes-Rahe stress scale. The primary endpoint was the odds of having a major stressful life event between CA and CO. A sample of 360 patients (CA = 120, CO = 240) was needed to achieve 80% power to detect an odds ratio (OR) of 2.00 versus the alternative of equal odds using χ ² = 0.05.

Results

Between May 2015 and December 2016, we enrolled 301 patients (CA = 102, CO = 199), matched for median age (CA = 64.4 years, CO = 63.9 years), sex (CA-Male = 48%, CO-Male = 49.2%), and smoking status (ever smoker, CA = 84%, CO = 85%). There was no difference in lifetime stressful life event rate between CA and CO (95% vs 93.9%; P = .68). However, CA were significantly more likely to have had a stressful event within the preceding 5 years than CO (CA = 77.4% vs CO = 65.8%; P = .03, OR = 1.78). β-blocker use was significantly higher among CO (CA = 29.4%, CO = 49.7%; P = .0007, OR = 0.42), suggesting a protective effect.

Conclusion

Patients with lung cancer are significantly more likely to have had a major stressful life event within the preceding 5 years. In addition, use of β-blockers may be protective against lung cancer.

SUBMITTER: Jafri SH

PROVIDER: S-EPMC6495441 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Major Stressful Life Events and Risk of Developing Lung Cancer: A Case-Control Study.

Jafri Syed H SH Ali Faisal F Mollaeian Arash A Mojiz Hasan Syed S Hussain Rahat R Akkanti Bindu B Williams Jessica J Shoukier Mahran M El-Osta Hazem H

Clinical Medicine Insights. Oncology 20190501

<h4>Background</h4>Lung cancer is the leading cause of cancer-related mortality and is strongly linked with smoking. We sought to determine whether major stressful life events (e.g. divorce) are also a risk factor for developing lung cancers.<h4>Methods</h4>We performed a matched case-control study. Cases (CA) were lung cancer patients diagnosed within the previous 12 months. Controls (CO) were patients without a prior history of malignancy. Data on major stressful life events were collected usi ...[more]

PMID: 31068757

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Dataset Information

Major Stressful Life Events and Risk of Developing Lung Cancer: A Case-Control Study.

Background

Methods

Results

Conclusion

Publications

Major Stressful Life Events and Risk of Developing Lung Cancer: A Case-Control Study.

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