Dataset Information

Association between trimester-specific gestational weight gain and childhood obesity at 5?years of age: results from Shanghai obesity cohort.

ABSTRACT:

Background

It is still unclear if and at which trimester gestational weight gain is related to childhood adiposity. Thus we aimed to evaluate the association between trimester-specific gestational weight gain and body-fat compositions in Chinese children.

Methods

Maternal gestational weight were measured by trained nurses every 2 to 4?weeks from the first prenatal care, and body-fat compositions of 407 children from the Shanghai Obesity Cohort at 5?years of age were measured by nutritionist through bioelectrical impedance analysis. Overweight/obesity of children was defined according to the criteria of International Obesity Task Force. Logistic and linear regression models adjusted for potential confounders were conducted to evaluate the associations of gestational weight gains with childhood obesity and body-fat compositions. Two-sided P-value ResultsGreater gestational weight gain in the 1^st-trimester was significantly associated with a higher risk of childhood overweight/obesity [OR: 1.40 (95% CI: 1.06, 1.86)], fat mass index [?: 0.25 (95% CI: 0.12, 0.38)], body fat percentage [?: 1.04 (95% CI: 0.43, 1.65)], and waist-to-height ratio [?: 0.005 (95% CI: 0.002, 0.008)]. A positive but nonsignificant association was found between greater 3^rd-trimester gestational weight gain and a higher risk of offspring overweight/obesity, and we speculated that the association between 2^nd-trimester gestational weight gain and offspring overweight/obesity is the "U" type.

Conclusions

Weight gain in the first trimester gestation is positively correlated with the risk of childhood overweight/obesity and with body adiposity distributions of children at 5?years of age. Weight gain should be well controlled and monitored from early pregnancy.

SUBMITTER: Lu W

PROVIDER: S-EPMC6495507 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Association between trimester-specific gestational weight gain and childhood obesity at 5 years of age: results from Shanghai obesity cohort.

Lu Wenyi W Zhang Xi X Wu Jiang J Mao Xiaomeng X Shen Xiuhua X Chen Qian Q Zhang Jun J Huang Lisu L Tang Qingya Q

BMC pediatrics 20190502 1

<h4>Background</h4>It is still unclear if and at which trimester gestational weight gain is related to childhood adiposity. Thus we aimed to evaluate the association between trimester-specific gestational weight gain and body-fat compositions in Chinese children.<h4>Methods</h4>Maternal gestational weight were measured by trained nurses every 2 to 4 weeks from the first prenatal care, and body-fat compositions of 407 children from the Shanghai Obesity Cohort at 5 years of age were measured by nu ...[more]

PMID: 31046723

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Project description:ObjectiveOur objective was to examine the associations of total and trimester-specific gestational weight gain (GWG) rate with postpartum maternal weight and cardiometabolic risk. We hypothesized that first-trimester GWG would be most strongly associated with long-term maternal health.Study designWe studied 801 women enrolled during the first trimester of pregnancy in the Boston-area Project Viva cohort 1999 through 2002. At 3 years postpartum we measured maternal weight, waist circumference (WC), and systolic blood pressure (SBP) and collected fasting blood from a subset. At 7 years postpartum we again measured weight and WC. We used multivariable linear regression to evaluate relations of total and trimester-specific GWG rate with weight change (vs self-reported prepregnancy weight) and WC at each time point, stratified by prepregnancy weight, as well as associations with SBP and insulin resistance at 3 years.ResultsMedian age at enrollment was 34.0 years (range, 16.4-44.9); 65% were white. Mean (SD) total GWG rate was 0.38 (0.14) kg/wk. Women gained weight faster during the second (0.47 [0.19] kg/wk) and third (0.44 [0.22] kg/wk) trimesters than the first (0.22 [0.22] kg/wk). Total and first-trimester GWG rate were most strongly associated with postpartum weight change. Among normal-weight women, each 1-SD increase in total and first-trimester GWG rate corresponded with 0.85 (95% confidence interval [CI], 0.07-1.63) kg and 2.08 (1.32-2.84) kg greater weight change at 3 and 7 years postpartum, respectively, but there was not strong evidence of association for either second- (-0.30 kg; 95% CI, -1.08 to 0.48) or third- (-0.26 kg; 95% CI, -1.08 to 0.55) trimester GWG. First-trimester GWG rate also related to 3-year postpartum weight change in overweight (2.28 kg; 95% CI, 0.95-3.61) and obese (2.47 kg; 95% CI, 0.98-3.97) women. Greater total and first-trimester GWG rate were associated with larger WC and higher SBP but not insulin resistance.ConclusionIn this observational cohort, first-trimester weight gain was more strongly associated with maternal weight retention as well as higher WC and blood pressure than second- or third-trimester gain. Interventions targeting GWG beginning very early in pregnancy may benefit long-term maternal health.