Ontology highlight
ABSTRACT:
SUBMITTER: Papp-Wallace KM
PROVIDER: S-EPMC6496078 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Papp-Wallace Krisztina M KM Bethel Christopher R CR Caillon Jocelyne J Barnes Melissa D MD Potel Gilles G Bajaksouzian Saralee S Rutter Joseph D JD Reghal Amokrane A Shapiro Stuart S Taracila Magdalena A MA Jacobs Michael R MR Bonomo Robert A RA Jacqueline Cédric C
Antimicrobial agents and chemotherapy 20190425 5
Impeding, as well as reducing, the burden of antimicrobial resistance in Gram-negative pathogens is an urgent public health endeavor. Our current antibiotic armamentarium is dwindling, while major resistance determinants (e.g., extended-spectrum β-lactamases [ESBLs]) continue to evolve and disseminate around the world. One approach to attack this problem is to develop novel therapies that will protect our current agents. AAI101 is a novel penicillanic acid sulfone β-lactamase inhibitor similar i ...[more]