Ontology highlight
ABSTRACT:
SUBMITTER: Manso BA
PROVIDER: S-EPMC6497058 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Manso Bryce A BA Zhang Henan H Mikkelson Molly G MG Gwin Kimberly A KA Secreto Charla R CR Ding Wei W Parikh Sameer A SA Kay Neil E NE Medina Kay L KL
Leukemia 20181005 3
The consequences of immune dysfunction in B-chronic lymphocytic leukemia (CLL) likely relate to the incidence of serious recurrent infections and second malignancies that plague CLL patients. The well-described immune abnormalities are not able to consistently explain these complications. Here, we report bone marrow (BM) hematopoietic dysfunction in early and late stage untreated CLL patients. Numbers of CD34<sup>+</sup> BM hematopoietic progenitors responsive in standard colony-forming unit (CF ...[more]