Ontology highlight
ABSTRACT:
SUBMITTER: Goh Q
PROVIDER: S-EPMC6497442 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Goh Qingnian Q Song Taejeong T Petrany Michael J MJ Cramer Alyssa Aw AA Sun Chengyi C Sadayappan Sakthivel S Lee Se-Jin SJ Millay Douglas P DP
eLife 20190423
Skeletal muscle adapts to external stimuli such as increased work. Muscle progenitors (MPs) control muscle repair due to severe damage, but the role of MP fusion and associated myonuclear accretion during exercise are unclear. While we previously demonstrated that MP fusion is required for growth using a supra-physiological model (Goh and Millay, 2017), questions remained about the need for myonuclear accrual during muscle adaptation in a physiological setting. Here, we developed an 8 week high- ...[more]