Cold agglutinin disease: current challenges and future prospects.
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ABSTRACT:
SUBMITTER: Berentsen S
PROVIDER: S-EPMC6497508 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Cold agglutinin disease: current challenges and future prospects.
Berentsen Sigbjørn S Röth Alexander A Randen Ulla U Jilma Bernd B Tjønnfjord Geir E GE
Journal of blood medicine 20190409
Cold agglutinin disease (CAD) is a complement-dependent, classical pathway-mediated immune hemolytic disease, accounting for 15-25% of autoimmune hemolytic anemia, and at the same time, a distinct clonal B-cell lymphoproliferative disorder of the bone marrow. The disease burden is often high, but not all patients require pharmacological treatment. Several therapies directed at the pathogenic B-cells are now available. Rituximab plus bendamustine or rituximab monotherapy should be considered firs ...[more]
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