Ontology highlight
ABSTRACT:
SUBMITTER: Qiu Q
PROVIDER: S-EPMC6497721 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Qiu Qi Q Mei Hailiang H Deng Xian X He Kaixuan K Wu Baixing B Yao Qingqing Q Zhang Jixiang J Lu Falong F Ma Jinbiao J Cao Xiaofeng X
Nature communications 20190502 1
RELATIVE OF EARLY FLOWERING 6 (REF6/JMJ12), a Jumonji C (JmjC)-domain-containing H3K27me3 histone demethylase, finds its target loci in Arabidopsis genome by directly recognizing the CTCTGYTY motif via its zinc-finger (ZnF) domains. REF6 tends to bind motifs located in active chromatin states that are depleted for heterochromatic modifications. However, the underlying mechanism remains unknown. Here, we show that REF6 preferentially bind to hypo-methylated CTCTGYTY motifs in vivo, and that CHG m ...[more]