Ontology highlight
ABSTRACT:
SUBMITTER: Lebowitz JJ
PROVIDER: S-EPMC6497934 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Lebowitz Joseph J JJ Pino Jose A JA Mackie Phillip M PM Lin Min M Hurst Cheyenne C Divita Keeley K Collins Anthony T AT Koutzoumis Dimitri N DN Torres Gonzalo E GE Khoshbouei Habibeh H
The Journal of biological chemistry 20190301 17
The dopamine transporter (DAT) regulates dopamine neurotransmission via reuptake of dopamine released into the extracellular space. Interactions with partner proteins alter DAT function and thereby dynamically shape dopaminergic tone important for normal brain function. However, the extent and nature of these interactions are incompletely understood. Here, we describe a novel physical and functional interaction between DAT and the voltage-gated K<sup>+</sup> channel Kv2.1 (potassium voltage-gate ...[more]