Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC64980 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
Huang Y Y Prasad M M Lemon W J WJ Hampel H H Wright F A FA Kornacker K K LiVolsi V V Frankel W W Kloos R T RT Eng C C Pellegata N S NS de la Chapelle A A
Proceedings of the National Academy of Sciences of the United States of America 20011201 26
Papillary thyroid carcinoma (PTC) is clinically heterogeneous. Apart from an association with ionizing radiation, the etiology and molecular biology of PTC is poorly understood. We used oligo-based DNA arrays to study the expression profiles of eight matched pairs of normal thyroid and PTC tissues. Additional PTC tumors and other tissues were studied by reverse transcriptase-PCR and immunohistochemistry. The PTCs showed concordant expression of many genes and distinct clustered profiles. Genes w ...[more]