RNA Degradation in Neurodegenerative Disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Weskamp K
PROVIDER: S-EPMC6498147 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
RNA Degradation in Neurodegenerative Disease.
Weskamp Kaitlin K Barmada Sami J SJ
Advances in neurobiology 20180101
Ribonucleic acid (RNA) homeostasis is dynamically modulated in response to changing physiological conditions. Tight regulation of RNA abundance through both transcription and degradation determines the amount, timing, and location of protein translation. This balance is of particular importance in neurons, which are among the most metabolically active and morphologically complex cells in the body. As a result, any disruptions in RNA degradation can have dramatic consequences for neuronal health. ...[more]
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