Dataset Information

Hepatitis B vaccination uptake in hard-to-reach populations in London: a cross-sectional study.

ABSTRACT:

Background

In the UK, hepatitis B virus (HBV) incidence is associated with migrants from particular high-burden countries and population groups deemed 'hard-to-reach' by standard healthcare services: the homeless, people who inject drugs and ex-prisoners. Currently, there is a national targeted HBV vaccine policy for such at-risk groups, but there is limited recent evidence about 1) the levels of vaccine uptake, 2) the factors associated with incomplete vaccination, and 3) reasons for incomplete vaccination.

Methods

A questionnaire capturing social and medical history, demographic factors and information about HBV vaccination status was completed by individuals deemed hard-to-reach due to socio-structural factors that criminalise, isolate and stigmatise who consented to participate in a randomised controlled trial of a peer intervention to promote engagement with hepatitis C services. The questionnaire also captured the reasons for incomplete vaccination. Descriptive, univariable and multivariable regression analyses were undertaken.

Results

Three hundred fourty six participants completed the questionnaire. 1) 52.3% (n =?181) reported full HBV vaccination. 2) Within a multivariable model adjusting for sociodemographic variables, the presence of one or two or more socio-structural factors that are included in the national targeted vaccination policy was associated with protection against incomplete HBV vaccination (51.7% vaccine coverage in those with one factor, odds ratio 0.43 [95% confidence interval 0.20-0.92]); 70.1% coverage with two or more factors, 0.19 [0.09-0.39]; overall p-value ConclusionWithin this study of HBV vaccination uptake among hard-to-reach population groups in London, UK, we document 52.3% coverage of the full vaccine course. Critically, although participants recommended for immunisation within national guidelines had an increased likelihood of receiving a complete vaccine course, we note surprisingly low coverage in the presence of the risk factors that are national indicators for vaccination. Public health bodies should make additional efforts to improve coverage in the hard-to-reach through improved vaccine delivery systems.

Trial registration

ISRCTN24707359 , Registered 19th October 2012.

SUBMITTER: Taylor JEB

PROVIDER: S-EPMC6498651 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Hepatitis B vaccination uptake in hard-to-reach populations in London: a cross-sectional study.

Taylor Josephine E B JEB Surey Julian J MacLellan Jennifer J Francis Marie M Abubakar Ibrahim I Stagg Helen R HR

BMC infectious diseases 20190502 1

<h4>Background</h4>In the UK, hepatitis B virus (HBV) incidence is associated with migrants from particular high-burden countries and population groups deemed 'hard-to-reach' by standard healthcare services: the homeless, people who inject drugs and ex-prisoners. Currently, there is a national targeted HBV vaccine policy for such at-risk groups, but there is limited recent evidence about 1) the levels of vaccine uptake, 2) the factors associated with incomplete vaccination, and 3) reasons for in ...[more]

PMID: 31046683

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Dataset Information

Hepatitis B vaccination uptake in hard-to-reach populations in London: a cross-sectional study.

Background

Methods

Results

Trial registration

Publications

Hepatitis B vaccination uptake in hard-to-reach populations in London: a cross-sectional study.

Similar Datasets

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