Ontology highlight
ABSTRACT:
SUBMITTER: Pascual T
PROVIDER: S-EPMC6498671 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Pascual Tomás T Martin Miguel M Fernández-Martínez Aranzazu A Paré Laia L Alba Emilio E Rodríguez-Lescure Álvaro Á Perrone Giuseppe G Cortés Javier J Morales Serafín S Lluch Ana A Urruticoechea Ander A González-Farré Blanca B Galván Patricia P Jares Pedro P Rodriguez Adela A Chic Nuria N Righi Daniela D Cejalvo Juan Miguel JM Tonini Giuseppe G Adamo Barbara B Vidal Maria M Villagrasa Patricia P Muñoz Montserrat M Prat Aleix A
Frontiers in oncology 20190426
<b>Background:</b> In hormone receptor-positive (HR+)/HER2-negative breast cancer, the HER2-enriched and Basal-like intrinsic subtypes are associated with poor outcome, low response to anti-estrogen therapy and high response to chemotherapy. To date, no validated biomarker exists to identify both molecular entities other than gene expression. <b>Methods:</b> PAM50 subtyping and immunohistochemical data were obtained from 8 independent studies of 1,416 HR+/HER2-negative early breast tumors. A non ...[more]