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Association of current Helicobacter pylori infection and metabolic factors with gastric cancer in 35,519 subjects: A cross-sectional study.

ABSTRACT:

Background

The effect of current infection of Helicobacter pylori on gastric cancer has rarely been studied in a large population. We investigated the association of current H. pylori infection and metabolic factors with gastric cancer in a large population.

Methods

Persons who made their first visit to the National Cancer Center for a health examination, including endoscopy and H. pylori testing using gastric tissue between 2003 and 2013, were included. The association of H. pylori with gastric cancer was estimated using odds ratios (ORs) and 95% confidence intervals (CIs).

Results

Among 35,519 people, 113 gastric cancer and 158 gastric dysplasia cases were detected. In the adjusted analysis, gastric cancer was associated with current H. pylori infection (OR, 2.39; 95% CI, 1.53-3.74), age (OR, 1.06; 95% CI 1.04-1.08), first-degree relatives with gastric cancer (OR, 2.08; 95% CI, 1.30-3.32) and hyperglycaemia (OR, 1.66; 95% CI, 1.04-2.65), whereas it was inversely associated with high-density lipoprotein (HDL) (OR, 0.49; 95% CI, 0.22-0.94). In the subanalysis, gastric cancer was associated with first-degree relatives with gastric cancer (OR, 3.23; 95% CI, 1.39-7.50) in the absence of H. pylori, whereas it was associated with hyperglycaemia (OR, 1.98; 95% CI, 1.16-3.39) in the presence of H. pylori.

Conclusions

Gastric cancer was associated with current H. pylori infection, hyperglycaemia, and low HDL levels in a large population.

SUBMITTER: Youn Nam S

PROVIDER: S-EPMC6498802 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Association of current <i>Helicobacter pylori</i> infection and metabolic factors with gastric cancer in 35,519 subjects: A cross-sectional study.

Youn Nam Su S Park Bum Joon BJ Nam Ji Hyung JH Nam Ji Hyung JH Ryu Kum Hei KH Kook Myeong-Cherl MC Kim Jeongseon J Lee Won Kee WK

United European gastroenterology journal 20181212 2

<h4>Background</h4>The effect of current infection of <i>Helicobacter pylori</i> on gastric cancer has rarely been studied in a large population. We investigated the association of current <i>H. pylori</i> infection and metabolic factors with gastric cancer in a large population.<h4>Methods</h4>Persons who made their first visit to the National Cancer Center for a health examination, including endoscopy and <i>H. pylori</i> testing using gastric tissue between 2003 and 2013, were included. The a ...[more]

PMID: 31080613

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