Ontology highlight
ABSTRACT:
SUBMITTER: Schwarz KJ
PROVIDER: S-EPMC6499373 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20180820 37
The first asymmetric cooperative Lewis base/palladium catalyzed benzylic alkylation of acyclic esters is reported. This reaction proceeds via stereodefined C1-ammonium enolate nucleophiles. Critical to its success was the identification of benzylic phosphate electrophiles, which were uniquely reactive. Alkylated products were obtained with very high levels of enantioselectivity, and this method has been applied toward the synthesis of the thrombin inhibitor DX-9065a. ...[more]