Sox2 Expression Marks Castration-Resistant Progenitor Cells in the Adult Murine Prostate.
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ABSTRACT:
SUBMITTER: McAuley E
PROVIDER: S-EPMC6499382 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Sox2 Expression Marks Castration-Resistant Progenitor Cells in the Adult Murine Prostate.
McAuley Erin E Moline Daniel D VanOpstall Calvin C Lamperis Sophia S Brown Ryan R Vander Griend Donald J DJ
Stem cells (Dayton, Ohio) 20190215 5
Identification of defined epithelial cell populations with progenitor properties is critical for understanding prostatic development and disease. Here, we demonstrate that Sox2 expression is enriched in the epithelial cells of the proximal prostate adjacent to the urethra. We use lineage tracing of Sox2-positive cells during prostatic development, homeostasis, and regeneration to show that the Sox2 lineage is capable of self-renewal and contributes to prostatic regeneration. Persisting luminal c ...[more]
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