Ontology highlight
ABSTRACT:
SUBMITTER: Miao W
PROVIDER: S-EPMC6499697 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Journal of proteome research 20190402 5
Kinases are among the most important families of enzymes involved in cell signaling. In this study, we employed a recently developed parallel-reaction monitoring (PRM)-based targeted proteomic method to examine the reprogramming of the human kinome during colorectal cancer (CRC) metastasis. We were able to quantify the relative expression of 299 kinase proteins in a pair of matched primary/metastatic CRC cell lines. We also found that, among the differentially expressed kinases, phosphoribosyl p ...[more]