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DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.

ABSTRACT: BACKGROUND:Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n?=?256) and colorectal cancer cases (n?=?95) and in pan-cancer data from The Cancer Genome Atlas (TCGA). RESULTS:Significant methylation loss at an intragenic site of TREX2 was a frequent trait in both patient cohorts (p?=?0.016 and

SUBMITTER: Weigel C 

PROVIDER: S-EPMC6499986 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer.

Weigel Christoph C   Chaisaingmongkol Jittiporn J   Assenov Yassen Y   Kuhmann Christine C   Winkler Volker V   Santi Irene I   Bogatyrova Olga O   Kaucher Simone S   Bermejo Justo L JL   Leung Suet Y SY   Chan Tsun L TL   Lasitschka Felix F   Bohrer Manfred H MH   Marx Alexander A   Haußen Roland Heyny-von RH   Herold-Mende Christel C   Dyckhoff Gerhard G   Boukamp Petra P   Delank Klaus W KW   Hörmann Karl K   Lippert Burkhard M BM   Baier Gerald G   Dietz Andreas A   Oakes Christopher C CC   Plass Christoph C   Becher Heiko H   Schmezer Peter P   Ramroth Heribert H   Popanda Odilia O  

Clinical epigenetics 20190503 1

<h4>Background</h4>Genetic aberrations in DNA repair genes are linked to cancer, but less is reported about epigenetic regulation of DNA repair and functional consequences. We investigated the intragenic methylation loss at the three prime repair exonuclease 2 (TREX2) locus in laryngeal (n = 256) and colorectal cancer cases (n = 95) and in pan-cancer data from The Cancer Genome Atlas (TCGA).<h4>Results</h4>Significant methylation loss at an intragenic site of TREX2 was a frequent trait in both p  ...[more]

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