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Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review.


ABSTRACT:

Introduction

First line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research question: in patients with BD, how does use of nutraceutical treatments compare with placebo in reducing depressive and mania symptoms?

Methods and analysis

Clinical trials will be identified through database searches using PubMed via PubMed, EMBASE via embase.com, Cochrane Central Register of Controlled Clinical Trials (CENTRAL) via cochranelibrary.com and CINAHL Complete via EBSCO. Search terms for BD and specific nutraceuticals (75 total search terms) will be used. Double-blind, randomised, controlled, clinical trials of adults with BD will be included in the review. Risk of bias will be assessed using the Cochrane Collaboration's tool for assessing risk of bias in randomised trials.

Ethics and dissemination

This review will only look at published data (already reviewed for ethical compliance); therefore, ethical approval is not required. We aim to publish the systematic review in a peer-reviewed journal and present at conferences.

Prospero registration number

CRD42019100745.

SUBMITTER: Ashton MM 

PROVIDER: S-EPMC6500254 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review.

Ashton Melanie M MM   Berk Michael M   Ng Chee H CH   Hopwood Malcolm M   Kavanagh Bianca B   Williams Lana J LJ   Sarris Jerome J   Dean Olivia M OM  

BMJ open 20190404 4


<h4>Introduction</h4>First line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research question: in patients with BD, how does use of nutraceutical treatments compare with placebo in reducing depressive and mania symptoms?<h4>Methods and analysis</h4>Clinical trials will be identified  ...[more]

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