Genome-wide association study of suicide attempt in a Mexican population: a study protocol.

ABSTRACT:

Introduction

Suicidality is a complex behaviour and a major health problem; the specific features that could predispose to suicidal behaviour have been extensively investigated, most frequently in European and Asian populations. Therefore, our aim is to present a protocol that will explore suicide attempt in Mexican individuals diagnosed with psychiatric disorders, through a genome-wide association study (GWAS).

Method and analysis

We will perform a GWAS by comparing 700 individuals who have suicide attempt history, with control subjects without suicide attempt history (n=500). The genotyping will be conducted using the Infinium PsychArray BeadChip and quality controls will be applied to single nucleotides (SNPs) genotyped. After that, we will perform the imputation using ref

SUBMITTER: Gonzalez-Castro TB 

PROVIDER: S-EPMC6500275 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature