Unknown

Dataset Information

0

Biomarkers of Exposure among U.S. Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).


ABSTRACT:

Background

Given the diverse cigar market and limited data on biomarker patterns by cigar type, we compared biomarkers of nicotine and tobacco toxicants among cigar smokers and other groups.

Methods

Using Wave 1 urinary biomarker data from 5,604 adults in the Population Assessment of Tobacco and Health (PATH) Study, we compared geometric mean concentrations among cigar-only smokers (all cigars and separately for traditional, cigarillo, and filtered cigars), cigarette-only smokers, dual cigar/cigarette smokers, and never users of tobacco. We calculated geometric mean ratios comparing groups with never users adjusting for sex, age, race/ethnicity, education and creatinine.

Results

Some day cigar-only smokers had lower biomarker concentrations than every day cigar-only smokers, but higher than never users. Every day cigar-only smokers (n = 61) had lower TNE-2 (cotinine+trans-3'-hydroxycotinine) compared to every day cigarette-only (n = 2217; P < 0.0001) and dual cigar/cigarette smokers (n = 601; P < 0.0001). Several biomarkers, including NNAL (NNK metabolite) and CYMA (metabolite of acrylonitrile), were comparable in these groups. In exploratory analyses, every day filtered cigar-only (n = 7) smokers had higher biomarker concentrations compared with every day traditional cigar-only smokers (n = 12) and cigarillo-only smokers (n = 24). Every day smokers of each cigar type were similar to exclusive cigarette smokers. For some biomarkers, particularly for every day filtered cigar-only smokers, concentrations were higher.

Conclusions

For some biomarkers, every day cigar-only smokers were comparable with every day cigarette-only smokers. Exploratory analyses suggest that biomarkers vary by cigar type with every day filtered cigar-only smokers having the highest concentrations.

Impact

High exposure to harmful constituents among cigar smokers is a continuing health issue.

SUBMITTER: Chang CM 

PROVIDER: S-EPMC6500461 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Biomarkers of Exposure among U.S. Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).

Chang Cindy M CM   Rostron Brian L BL   Chang Joanne T JT   Corey Catherine G CG   Kimmel Heather L HL   Sosnoff Connie S CS   Goniewicz Maciej L ML   Edwards Kathryn C KC   Hatsukami Dorothy K DK   Wang Yuesong Y   Del Valle-Pinero Arseima Y AY   Yang Maocheng M   Travers Mark J MJ   Arnstein Stephen S   Taylor Kristie K   Conway Kevin K   Ambrose Bridget K BK   Borek Nicolette N   Hyland Andrew A   Wang Lanqing L   Blount Benjamin C BC   van Bemmel Dana M DM  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20190207 5


<h4>Background</h4>Given the diverse cigar market and limited data on biomarker patterns by cigar type, we compared biomarkers of nicotine and tobacco toxicants among cigar smokers and other groups.<h4>Methods</h4>Using Wave 1 urinary biomarker data from 5,604 adults in the Population Assessment of Tobacco and Health (PATH) Study, we compared geometric mean concentrations among cigar-only smokers (all cigars and separately for traditional, cigarillo, and filtered cigars), cigarette-only smokers,  ...[more]

Similar Datasets

| S-EPMC6726522 | biostudies-literature
| S-EPMC6397770 | biostudies-literature
| S-EPMC6265905 | biostudies-other
| S-EPMC7680301 | biostudies-literature
| S-EPMC8254764 | biostudies-literature
| S-EPMC6236070 | biostudies-literature
| S-EPMC7504577 | biostudies-literature
| S-EPMC10381103 | biostudies-literature
| S-EPMC7079166 | biostudies-literature
| S-EPMC6331224 | biostudies-literature