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Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network.

ABSTRACT: Recent studies have indicated that EGR1 is a direct regulator of tumor suppressors including TGF?1, PTEN, and p53. The Myb-like transcription factor Dmp1 is a physiological regulator of the Arf-p53 pathway through transactivation of the Arf promoter and physical interaction of p53. The Dmp1 promoter has binding sites for Egr proteins, and Egr1 is a target for Dmp1. Crosstalks between p53 and PTEN have been reported. The Egr1-Dmp1-Arf-p53-Pten pathway displays multiple modes of interaction with each other, suggesting the existence of a functional network of tumor suppressors that maintain normal cell growth and prevent the emergence of incipient cancer cells.

SUBMITTER: Inoue K

PROVIDER: S-EPMC6500763 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network.

Inoue Kazushi K Fry Elizabeth A EA

Cancer investigation 20181105 9-10

Recent studies have indicated that EGR1 is a direct regulator of tumor suppressors including TGFβ1, PTEN, and p53. The Myb-like transcription factor Dmp1 is a physiological regulator of the Arf-p53 pathway through transactivation of the Arf promoter and physical interaction of p53. The Dmp1 promoter has binding sites for Egr proteins, and Egr1 is a target for Dmp1. Crosstalks between p53 and PTEN have been reported. The Egr1-Dmp1-Arf-p53-Pten pathway displays multiple modes ...[more]

PMID: 30396285

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