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A microRNA switch controls dietary restriction-induced longevity through Wnt signaling.

ABSTRACT: Dietary restriction (DR) is known to have a potent and conserved longevity effect, yet its underlying molecular mechanisms remain elusive. DR modulates signaling pathways in response to nutrient status, a process that also regulates animal development. Here, we show that the suppression of Wnt signaling, a key pathway controlling development, is required for DR-induced longevity in Caenorhabditis elegans We find that DR induces the expression of mir-235, which inhibits cwn-1/WNT4 expression by binding to the 3'-UTR The "switch-on" of mir-235 by DR occurs at the onset of adulthood, thereby minimizing potential disruptions in development. Our results therefore implicate that DR controls the adult lifespan by using a temporal microRNA switch to modulate Wnt signaling.

SUBMITTER: Xu Y

PROVIDER: S-EPMC6500965 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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A microRNA switch controls dietary restriction-induced longevity through Wnt signaling.

Xu Yunpeng Y He Zhidong Z Song Mengjiao M Zhou Yifei Y Shen Yidong Y

EMBO reports 20190314 5

Dietary restriction (DR) is known to have a potent and conserved longevity effect, yet its underlying molecular mechanisms remain elusive. DR modulates signaling pathways in response to nutrient status, a process that also regulates animal development. Here, we show that the suppression of Wnt signaling, a key pathway controlling development, is required for DR-induced longevity in Caenorhabditis elegans We find that DR induces the expression of mir-235, which inhibits cwn-1 ...[more]

PMID: 30872315

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