Ontology highlight
ABSTRACT:
SUBMITTER: Hara K
PROVIDER: S-EPMC6501013 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Hara Kodai K Kinoshita Kazuhisa K Migita Tomoko T Murakami Kei K Shimizu Kenichiro K Takeuchi Kozo K Hirano Tatsuya T Hashimoto Hiroshi H
EMBO reports 20190311 5
Condensin I is a multi-protein complex that plays an essential role in mitotic chromosome assembly and segregation in eukaryotes. It is composed of five subunits: two SMC (SMC2 and SMC4), a kleisin (CAP-H), and two HEAT-repeat (CAP-D2 and CAP-G) subunits. Although balancing acts of the two HEAT-repeat subunits have been demonstrated to enable this complex to support the dynamic assembly of chromosomal axes in vertebrate cells, its underlying mechanisms remain poorly understood. Here, we report t ...[more]