MicroRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer.

ABSTRACT:

Background

One-third of cervical cancer patients are still diagnosed at advanced stages. The five-year survival rate is decreased in about 50% of advanced stage cervical cancer patients worldwide, and the clinical outcomes are remarkably varied and difficult to predict. One of the miRNAs known to be associated with cancer tumorigenesis is miR-944. However, the prognostic value of miR-944 in cervical cancer has not been fully investigated. The aim of this study was to analyze clinical significance and prognostic value of miR-944 in cervical cancer.

Methods

The expression levels of miR-944 were detected using quantitative reverse transcription polymerase chain reaction in five types of cervical cancer cell lines and 116 formalin-fixed paraffin-embedded (FFPE) cervical tissues. The association between the expression levels of miR-944 and prognostic value was analyzed using the Kaplan-Meier analysis and Cox proportional hazards model.

Results

The expression levels of miR-944 in cervical cancer tissues were significantly higher compared with those in normal tissues (P?ConclusionsThese results suggest that miR-944 may be used as a novel biomarker for improving prognosis and as a potential therapeutic target.

SUBMITTER: Park S 

PROVIDER: S-EPMC6501303 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature