Dataset Information

Association of pathway mutation with survival after recurrence in colorectal cancer patients treated with adjuvant fluoropyrimidine and oxaliplatin chemotherapy.

ABSTRACT:

Background

Although the prognostic biomarkers associated with colorectal cancer (CRC) survival are well known, there are limited data on the association between the molecular characteristics and survival after recurrence (SAR). The purpose of this study was to assess the association between pathway mutations and SAR.

Methods

Of the 516 patients with stage III or high risk stage II CRC patients treated with surgery and adjuvant chemotherapy, 87 who had distant recurrence were included in the present study. We analyzed the association between SAR and mutations of 40 genes included in the five critical pathways of CRC (WNT, P53, RTK-RAS, TGF-?, and PI3K).

Results

Mutation of genes within the WNT, P53, RTK-RAS, TGF-?, and PI3K pathways were shown in 69(79.3%), 60(69.0%), 57(65.5%), 21(24.1%), and 19(21.8%) patients, respectively. Patients with TGF-? pathway mutation were younger and had higher incidence of mucinous adenocarcinoma (MAC) histology and microsatellite instability-high. TGF-? pathway mutation (median SAR of 21.6 vs. 44.4?months, p?=?0.021) and MAC (20.0 vs. 44.4?months, p?=?0.003) were associated with poor SAR, and receiving curative resection after recurrence was associated with favorable SAR (Not reached vs. 23.6?months, p?ConclusionsMutation in genes within TGF-? pathway may have negative prognostic role for SAR in CRC. Other pathway mutations were not associated with SAR.

SUBMITTER: Lee DW

PROVIDER: S-EPMC6501409 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Association of pathway mutation with survival after recurrence in colorectal cancer patients treated with adjuvant fluoropyrimidine and oxaliplatin chemotherapy.

Lee Dae-Won DW Han Sae-Won SW Cha Yongjun Y Bae Jeong Mo JM Kim Hwang-Phill HP Lyu Jaemyun J Han Hyojun H Kim Hyoki H Jang Hoon H Bang Duhee D Won Jae-Kyung JK Jeong Seung-Yong SY Park Kyu Joo KJ Kang Gyeong Hoon GH Kim Tae-You TY

BMC cancer 20190506 1

<h4>Background</h4>Although the prognostic biomarkers associated with colorectal cancer (CRC) survival are well known, there are limited data on the association between the molecular characteristics and survival after recurrence (SAR). The purpose of this study was to assess the association between pathway mutations and SAR.<h4>Methods</h4>Of the 516 patients with stage III or high risk stage II CRC patients treated with surgery and adjuvant chemotherapy, 87 who had distant recurrence were inclu ...[more]

PMID: 31060539

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Dataset Information

Association of pathway mutation with survival after recurrence in colorectal cancer patients treated with adjuvant fluoropyrimidine and oxaliplatin chemotherapy.

Background

Methods

Results

Publications

Association of pathway mutation with survival after recurrence in colorectal cancer patients treated with adjuvant fluoropyrimidine and oxaliplatin chemotherapy.

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