Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC6501643 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Wang Jing J Varin Thibault T Vieth Michal M Elkins Jonathan M JM
Open biology 20190401 4
The RIO kinases (RIOKs) are a universal family of atypical kinases that are essential for assembly of the pre-40S ribosome complex. Here, we present the crystal structure of human RIO kinase 2 (RIOK2) bound to a specific inhibitor. This first crystal structure of an inhibitor-bound RIO kinase reveals the binding mode of the inhibitor and explains the structure-activity relationship of the inhibitor series. The inhibitor binds in the ATP-binding site and forms extensive hydrophobic interactions w ...[more]