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A new standard reference film for oxygen gas transmission measurements.


ABSTRACT: A novel reference film was characterized to improve the oxygen gas transmission measurement accuracy of plastic materials for pharmaceutical packaging. The material processing, homogeneity, stability, jointly determined value and uncertainty evaluation were discussed. The film is the first reference film characterized by multiple laboratories using both manometric and coulometric methods. The oxygen transmission rate of the reference film was 20.53 with the expanded uncertainty of 1.36. The newly characterized reference film can be used in the calibration and self-calibration of oxygen transmission measurement equipment and analytical method verification to improve the measurement accuracy and achieve traceable data.

SUBMITTER: Xie LG 

PROVIDER: S-EPMC6502387 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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A new standard reference film for oxygen gas transmission measurements.

Xie Lan-Gui LG   Zhao Xia X   Dou Si-Hong SH   Tang Long L   Sun Hui-Min HM  

Royal Society open science 20190410 4


A novel reference film was characterized to improve the oxygen gas transmission measurement accuracy of plastic materials for pharmaceutical packaging. The material processing, homogeneity, stability, jointly determined value and uncertainty evaluation were discussed. The film is the first reference film characterized by multiple laboratories using both manometric and coulometric methods. The oxygen transmission rate of the reference film was 20.53 with the expanded uncertainty of 1.36. The newl  ...[more]

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