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Automated concentration of [18F]fluoride into microliter volumes.


ABSTRACT: Concentration of [18F]fluoride has been mentioned in literature, however, reports have lacked details about system designs, operation, and performance. Here, we describe in detail a compact, fast, fully-automated concentration system based on a micro-sized strong anion exchange cartridge. The concentration of radionuclides enables scaled-up microfluidic synthesis. Our system can also be used to provide highly concentrated [18F]fluoride with minimal water content. We demonstrate how the concentrator can produce varying concentrations of [18F]fluoride for the macroscale synthesis of N-boc-5-[18F]fluoroindole without an azeotropic drying process, while enabling high starting radioactivity. By appropriate choice of solid-phase resin, flow conditions, and eluent solution, we believe this approach can be extended beyond [18F]fluoride to other radionuclides.

SUBMITTER: Chao PH 

PROVIDER: S-EPMC6502507 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Automated concentration of [<sup>18</sup>F]fluoride into microliter volumes.

Chao Philip H PH   Lazari Mark M   Hanet Sebastian S   Narayanam Maruthi Kumar MK   Murphy Jennifer M JM   van Dam R Michael RM  

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20180623


Concentration of [<sup>18</sup>F]fluoride has been mentioned in literature, however, reports have lacked details about system designs, operation, and performance. Here, we describe in detail a compact, fast, fully-automated concentration system based on a micro-sized strong anion exchange cartridge. The concentration of radionuclides enables scaled-up microfluidic synthesis. Our system can also be used to provide highly concentrated [<sup>18</sup>F]fluoride with minimal water content. We demonst  ...[more]

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