Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC6502987 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Liu Chenxing C Everall Ian I Pantelis Christos C Bousman Chad C
Frontiers in genetics 20190430
Schizophrenia is a psychiatric disorder with a worldwide prevalence of ∼1%. The high heritability and reduced fertility among schizophrenia patients have raised an evolutionary paradox: why has negative selection not eliminated schizophrenia associated alleles during evolution? To address this question, we examined evolutionary markers, known as modern-human-specific (MD) sites and archaic-human-specific sites, using existing genome-wide association study (GWAS) data from 34,241 individuals with ...[more]