Ontology highlight
ABSTRACT:
SUBMITTER: Nilsson D
PROVIDER: S-EPMC6503019 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nilsson Daniel D Heglind Mikael M Arani Zahra Z Enerbäck Sven S
Physiological reports 20190501 9
Foxc2 is one of the earliest podocyte markers during glomerular development. To circumvent embryonic lethal effects of global deletion of Foxc2, and to specifically investigate the role of Foxc2 in podocytes, we generated mice with a podocyte-specific Foxc2 deletion. Mice carrying the homozygous deletion developed early proteinuria which progressed rapidly into end stage kidney failure and death around postnatal day 10. Conditional loss of Foxc2 in podocytes caused typical characteristics of pod ...[more]