Ontology highlight
ABSTRACT:
SUBMITTER: Booth A
PROVIDER: S-EPMC6503128 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Booth Andrew A Marklew Christopher J CJ Ciani Barbara B Beales Paul A PA
iScience 20190420
Artificial cells can shed new light on the molecular basis for life and hold potential for new chemical technologies. Inspired by how nature dynamically regulates its membrane compartments, we aim to repurpose the endosomal sorting complex required for transport (ESCRT) to generate complex membrane architectures as suitable scaffolds for artificial cells. Purified ESCRT-III components perform topological transformations on giant unilamellar vesicles to create complex "vesicles-within-a-vesicle" ...[more]