Dataset Information

Functional variants of lncRNA LINC00673 and gastric cancer susceptibility: a case-control study in a Chinese population.

ABSTRACT: Background: Two genome-wide association studies (GWASs) identified LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer. Methods: To investigate the association between LINC00673 polymorphisms and gastric cancer (GC) risk, and the impact of gene-environmental interaction on GC risk, we conducted this case-control study in a Chinese population. Results: We found rs11655237 significantly increased susceptibility of GC in the Chinese population (OR=1.29; 95% CI=1.12-1.48; P=4.1×10-4), and a significant interaction was found between rs11655237 and Helicobacter pylori infection (P=0.006). Expression of LINC00673 was significantly higher in adjacent normal tissues than in paired cancer tissues (P<0.001) and significantly lower in the cancer or paired adjacent normal tissues of GC patients with rs11655237 allele A than in those with rs11655237 allele G (P<0.001). Mechanism exploration found that, the construct with the rs11655237[A] allele had significantly reduced luciferase activity in the presence of miR-1231, and this effect could be completely rescued when miR-1231 inhibitor was present. Conclusion: Our results indicate that LINC00673 rs11655237 is associated with an increased GC risk, possibly by down-regulating LINC00673 expression through creating a miR-1231 binding site.

SUBMITTER: Zhao K

PROVIDER: S-EPMC6503345 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Functional variants of lncRNA LINC00673 and gastric cancer susceptibility: a case-control study in a Chinese population.

Zhao Kexin K Zhang Rui R Li Tiantian T Xiong Zhifan Z

Cancer management and research 20190501

Background: Two genome-wide association studies (GWASs) identified LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer. Methods: To investigate the association between LINC00673 polymorphisms and gastric cancer (GC) risk, and the impact of gene-environmental interaction on GC risk, we conducted this case-control study in a Chinese population. Results: We found rs11655237 significantly increased susceptibility of GC in the Chinese population (OR=1.29; ...[more]

PMID: 31118802

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Project description:PurposeHOX transcript antisense RNA (HOTAIR) plays important roles in carcinogenesis of various kinds of malignant tumors, including lung cancer. Single nucleotide polymorphisms (SNPs) in HOTAIR were reported to be associated with susceptibility of several kinds of cancers. The present study assessed the associations between three SNPs (rs4759314, rs12826786, and rs920778) and lung cancer susceptibility, as well as gene-environment interaction between smoking exposure and the polymorphisms.Patients and methodsA case-control study including 551 patients and 543 healthy controls was performed. The associations between SNPs and lung cancer susceptibility were assessed by logistic regression model.Resultsrs4759314 was observed to increase the susceptibility of lung cancer, lung adenocarcinoma, squamous lung cancer, and small cell lung cancer statistically significantly (OR of 4.048 for lung cancer; 3.584 for lung adenocarcinoma; 4.671 for squamous lung cancer; 4.502 for small cell lung cancer). In stratified analysis for sex and smoking exposure, rs4759314 GG and AG genotype was also observed to increase the risk of lung cancer statistically significantly (OR of 5.221 for male; 3.491 for female; 3.653 for nonsmoking individuals; 4.458 for smoking individuals). Results of gene-environment interaction analysis showed that there was no interaction between smoking exposure and rs4759314 on additive scale. Results of logistic regression model suggested that the interaction between smoking and rs4759314 was statistically significant on multiplicative scale. rs12826786 CT genotype carriers and T allele could decrease the risk of developing lung cancer (OR of 0.751 for CT carriers; 0.785 for T allele), and in dominant model, TC and TT genotype carriers also have a 0.249-fold decrease risk compared with CC genotype carriers. In stratified analysis for smoking exposure, TC and TT have a 0.432-fold decreased risk compared with CC genotype carriers.ConclusionHOTAIR rs4759314 and rs12826786 were associated with lung cancer susceptibility in Chinese Han population.

Dataset Information

Functional variants of lncRNA LINC00673 and gastric cancer susceptibility: a case-control study in a Chinese population.

Publications

Functional variants of lncRNA LINC00673 and gastric cancer susceptibility: a case-control study in a Chinese population.

Similar Datasets

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