Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial.
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ABSTRACT:
SUBMITTER: Barcelos NM
PROVIDER: S-EPMC6503670 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial.
Barcelos Nicole M NM Van Ness Peter H PH Wagner Allison F AF MacAvoy Martha G MG Mecca Adam P AP Anderson George M GM Trentalange Mark M Hawkins Keith A KA Sano Mary M Arnsten Amy F T AFT van Dyck Christopher H CH
Neurobiology of aging 20180531
This study evaluated the effect of the alpha-2A-adrenoceptor agonist guanfacine on prefrontally mediated cognitive functions, as well as quality of life and global function in healthy older participants. One hundred twenty-three participants aged 75 years and older were randomly assigned to guanfacine 0.5 mg, 0.1 mg, or placebo daily for 12 weeks. The primary outcome measure was the change in z-score for 6 prefrontal executive function tasks over 12 weeks (PEF6). Neither dose of guanfacine impro ...[more]
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