Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
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ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC6504213 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
Yang Chongbo C Lu Ming M Chen Wenbin W He Zhao Z Hou Xu X Feng Mei M Zhang Hongjia H Bo Tao T Zhou Xiaoming X Yu Yong Y Zhang Haiqing H Zhao Meng M Wang Laicheng L Yu Chunxiao C Gao Ling L Jiang Wenjian W Zhang Qunye Q Zhao Jiajun J
The Journal of experimental medicine 20190402 5
Subclinical hypothyroidism is associated with cardiovascular diseases, yet the underlying mechanism remains largely unknown. Herein, in a common population (<i>n</i> = 1,103), TSH level was found to be independently correlated with both carotid plaque prevalence and intima-media thickness. Consistently, TSH receptor ablation in <i>ApoE</i> <sup>-/-</sup> mice attenuated atherogenesis, accompanied by decreased vascular inflammation and macrophage burden in atherosclerotic plaques. These results w ...[more]
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