Ontology highlight
ABSTRACT:
SUBMITTER: Jen HI
PROVIDER: S-EPMC6504235 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Jen Hsin-I HI Hill Matthew C MC Tao Litao L Sheng Kuanwei K Cao Wenjian W Zhang Hongyuan H Yu Haoze V HV Llamas Juan J Zong Chenghang C Martin James F JF Segil Neil N Groves Andrew K AK
eLife 20190429
The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of hearing. In contrast, the adult vestibular system can produce new hair cells in response to damage, or by reprogramming of supporting cells with the hair cell transcription factor Atoh1. We used RNA-seq and ATAC-seq to probe the transcriptional and epigenetic responses of utricle supporting cells to damage and Atoh1 transduction. We show that the regenerative response of the utricle correlates with a more ...[more]