Ontology highlight
ABSTRACT:
SUBMITTER: Danahy DB
PROVIDER: S-EPMC6504616 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Danahy Derek B DB Jensen Isaac J IJ Griffith Thomas S TS Badovinac Vladimir P VP
Journal of immunology (Baltimore, Md. : 1950) 20190410 10
Malignancy increases sepsis incidence 10-fold and elevates sepsis-associated mortality. Advances in treatment have improved survival of cancer patients shortly after sepsis, but there is a paucity of information on how sepsis impacts cancer growth, development, and prognosis. To test this, cecal ligation and puncture surgery was performed on B16 melanoma-bearing mice to show that sepsis has detrimental effects in hosts with advanced tumors, leading to increased mortality. Surprisingly, mice expe ...[more]