Dataset Information

Developing a case definition for type 1 diabetes mellitus in a primary care electronic medical record database: an exploratory study.

ABSTRACT:

Background

Identifying cases of disease in primary care electronic medical records (EMRs) is important for surveillance, research, quality improvement and clinical care. We aimed to develop and validate a case definition for type 1 diabetes mellitus using EMRs.

Methods

For this exploratory study, we used EMR data from the Southern Alberta Primary Care Network within the Canadian Primary Care Sentinel Surveillance Network (CPCSSN), for the period 2008 to 2016. For patients identified as having diabetes mellitus according to the existing CPCSSN case definition, we asked family physicians to confirm the diabetes subtype, to create the reference standard. We used 3 decision-tree classification algorithms and least absolute shrinkage and selection operator logistic regression to identify variables that correctly distinguished between type 1 and type 2 diabetes cases.

Results

We identified a total of 1309 people with type 1 or type 2 diabetes, 110 of whom were confirmed by their physicians as having type 1 diabetes. Two machine learning algorithms were useful in identifying these cases in the EMRs. The first algorithm used "type 1" text words or age less than 22 years at time of initial diabetes diagnosis; this algorithm had sensitivity 42.7% (95% confidence interval [CI] 33.5%-52.5%), specificity 99.3% (95% CI 98.6%-99.7%), positive predictive value 85.5% (95% CI 72.8%-93.1%) and negative predictive value 94.9% (95% CI 93.5%-96.1%). The second algorithm used a combination of free-text terms, insulin prescriptions and age; it had sensitivity 87.3% (95% CI 79.2%-92.6%), specificity 85.4% (95% CI 83.2%-87.3%), positive predictive value 35.6% (95% CI 29.9%-41.6%) and negative predictive value 98.6% (95% CI 97.7%-99.2%).

Interpretation

We used machine learning to develop and validate 2 case definitions that achieve different goals in distinguishing between type 1 and type 2 diabetes in CPCSSN data. Further validation and testing with a larger and more diverse sample are recommended.

SUBMITTER: Lethebe BC

PROVIDER: S-EPMC6504632 | biostudies-literature | 2019 Apr-Jun

REPOSITORIES: biostudies-literature

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Publications

Developing a case definition for type 1 diabetes mellitus in a primary care electronic medical record database: an exploratory study.

Lethebe B Cord BC Williamson Tyler T Garies Stephanie S McBrien Kerry K Leduc Charles C Butalia Sonia S Soos Boglarka B Shaw Marta M Drummond Neil N

CMAJ open 20190401 2

<h4>Background</h4>Identifying cases of disease in primary care electronic medical records (EMRs) is important for surveillance, research, quality improvement and clinical care. We aimed to develop and validate a case definition for type 1 diabetes mellitus using EMRs.<h4>Methods</h4>For this exploratory study, we used EMR data from the Southern Alberta Primary Care Network within the Canadian Primary Care Sentinel Surveillance Network (CPCSSN), for the period 2008 to 2016. For patients identifi ...[more]

PMID: 31061005

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Dataset Information

Developing a case definition for type 1 diabetes mellitus in a primary care electronic medical record database: an exploratory study.

Background

Methods

Results

Interpretation

Publications

Developing a case definition for type 1 diabetes mellitus in a primary care electronic medical record database: an exploratory study.

Similar Datasets

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