Ontology highlight
ABSTRACT:
SUBMITTER: Onozato ML
PROVIDER: S-EPMC6504678 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Onozato Maristela L ML Yapp Clarence C Richardson Douglas D Sundaresan Tilak T Chahal Varun V Lee Jesse J Sullivan James P JP Madden Marisa W MW Shim Hyo S HS Liebers Matthew M Ho Quan Q Maheswaran Shyamala S Haber Daniel A DA Zheng Zongli Z Clancy Brian B Elliott Hunter L HL Lennerz Jochen K JK Iafrate A John AJ
The Journal of molecular diagnostics : JMD 20190309 3
The quantification of changes in gene copy number is critical to our understanding of tumor biology and for the clinical management of cancer patients. DNA fluorescence in situ hybridization is the gold standard method to detect copy number alterations, but it is limited by the number of genes one can quantify simultaneously. To increase the throughput of this informative technique, a fluorescent bar-code system for the unique labeling of dozens of genes and an automated image analysis algorithm ...[more]